server stored highscores

I am working on a website that will host a lot of games and people will be able to play the games but getting straight to the point I need to create highscores so when the player loses the game it will store their score in a database under their username. I was wondering how I would go about doing this. Please try to post different ways of doing this so I can choose the best for what I am doing. What I am thinking about is something like on www.miniclip.com that when you lose a GUI pops up with the highscores etc.

Alex